Cardiovascular and Metabolic Diseases
The public impact of many pieces of published School research is clear. Research by Taylor et al., (2017) conducted at the University of Oxford, has shown survival rates for patients with heart failure have not improved since 1998. This research was reported in 90 local, national and international print and online news outlets between January and September 2017, including The Telegraph, The Express the Mail Online , and Yahoo News .
School research has also been highlighted in professional publications. Doctoral researcher Benjamin Fletcher and researcher partners at both Oxford and Cambridge had their publication about self-monitoring blood pressure in patients with hypertension (Fletcher et al., 2016) featured in the British Journal of General Practice. The research presented the findings of a survey (with 300 GPs) to assess current practice of using self-monitoring of blood pressure (SMBP) for the control of hypertension.
Oxford PIs led a series of trials (BAFTA, SAFE) and SRs that have helped shape international and NICE atrial fibrillation guidelines for screening and treatment strategies to prevent stroke. We also developed and tested novel anticoagulation strategies for safer and more effective anticoagulation in primary care (utilising computerised clinical decision support, near patient testing, and nurse training) which was adopted by the NHS as their preferred UK model. Results from studies undertaken by the EBM group showed self-monitoring of oral anticoagulation decreases thromboembolic events by half, and major haemorrhage. An international collaboration of trialists showed reductions in the subset of patients with artificial heart valves was even greater, with a 2/3rd reduction in thromboembolic events at five years. The work was used to underpin the Government white paper on shared decision making and is included in clinical knowledge summaries, the British Committee for Standards in Haematology. Internationally the implications for practice are included in the 9th American College of Chest Physicians Evidence-Based Clinical Practice Guidelines on Antithrombotic & Thrombolytic Therapy.