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FR 14

Title Principal Investigator Start date End date
382. Establishing research priorities to improve the management of patients with advanced heart failure using the James Lind Alliance method. Rachel Johnson 1 October 2017 1 April 2019
383. The TEST (Trial of Eczema allergy Screening Tests) Study: feasibility randomised controlled trial with economic scoping and nested qualitative study Matt Ridd 1 October 2017 30 November 2019
384. Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care (Optimise-HFpEF) Christi Deaton 1 October 2017 30 June 2020
386. Quantifying variation in UK primary care test use: A 15 year retrospective analysis of temporal and geographical variation in test use. Jack O'Sullivan 1 October 2017 1 October 2018
387. Microbiology of throat swabs collected when patients present to primary care with acute cough Kyle Knox 1 February 2018 30 August 2018
388. Evaluating the impact of the 2011 NICE Hypertension Guideline on the Management of Hypertension in Primary Care and Subsequent Outcomes Richard McManus 1 October 2017 30 December 2018
389. Expectation Management for Patients in Primary Care: Developing and Feasibility Testing a New Digital Intervention for Practitioners Hazel Everitt 1 October 2018 30 September 2019
390. Improving the evidence-base for primary care: NIHR Evidence Synthesis working group Carl Heneghan 1 October 2017 30 September 2020
385. D-Mannose to prevent Recurrent UTI: a double blind randomised placebo controlled trial Gail Hayward 1 October 2017 31 March 2020

FR 13

Title Principal Investigator Start date End date
368. Establishing research priorities to improve the management of patients with advanced heart failure using the James Lind Alliance method Clare Taylor 1 April 2017 30 September 2018
370. Understanding the support needs of people with chronic fatigue syndrome/ myalgic encephalomyelitis (CFS/ME): A qualitative meta-synthesis Carolyn Chew-Graham 1 September 2017 30 June 2018
374. Prolonged Antibiotic Use, Inflammation and Obesity (PROBITY) - A Retrospective Cohort Study Mark Lown 1 April 2017 31 March 2018
378. Management of anxiety and depression in frail older people: a qualitative study Rachael Frost 1 October 2017 31 May 2018
355. Preventing depression in the community by voluntary sector providers Waquas Waheed 1 June 2017 31 May 2018
342. Development of simple risk models incorporating modifiable risk factors for the most common preventable cancers using EPIC-Norfolk Juliet Usher-Smith 1 April 2017 31 March 2018
367. What is the value of diagnostic tests at presentation in the ambulatory care setting to identify serious bacterial infections in the elderly? A systematic review and meta-analysis Kome Gbinigie 1 June 2017 30 September 2018
371. Investigating the possible role of Andrographis paniculata as a symptomatic intervention for acute respiratory tract infections Miriam Santer 1 April 2017 30 April 2018
373. Investigating the feasibility of a mobile mindfulness-based digital intervention for patients with asthma Ben Ainsworth 1 April 2017 31 March 2018
352. Getting a Better View of Osteoarthritis Trajectories and Variability (OA-TV): systematic reviews and stakeholder engagement Martin Thomas 1 April 2017 31 December 2017
356. Disease and healthcare usage in the 10th decade – Newcastle 85+ Study 10 year follow up. Rachel Duncan 1 June 2017 31 May 2018
360. Health and wellbeing of older adults in care homes: What can we learn from existing longitudinal studies? Barbara Hanratty 1 October 2017 31 March 2018
358. Clinical system-generated alerts to improve GP practice for patients with low health literacy and numeracy: a feasibility study Gill Rowlands 1 April 2017 31 December 2017
349. Rheumatological and inflammatory conditions as risk factors for self-harm and suicide. A retrospective cohort study James Prior 1 April 2017 31 March 2018
348. Glucocorticoid induced complications in patients with polymyalgia rheumatica and giant cell arteritis Toby Helliwell 1 April 2017 30 September 2018
347. Management of Patients with Heart Failure with Preserved Ejection Fraction: What do Patients and Providers Need and Want? Christi Deaton 1 May 2017 31 January 2018
338. Exploring the barriers and facilitators to identifying anxiety disorders in primary care Maria Barnes 1 September 2017 30 November 2018
346. Improving the diagnostic process for patients with bladder and kidney cancer: variations in pre-diagnostic clinical activities and events 1 April 2017 31 March 2018
337. Investigating the impact of the introduction of a named GP assigned to patients 75 and over on their continuity of care and emergency hospital admission Peter Tammes 1 September 2017 31 January 2018
362. Evaluation of the impact of the national ‘Safe At Home’ scheme on injury rates in children under 5 using secondary care data. Elizabeth Orton 1 April 2017 31 March 2018
366. Parents’ perceptions of Antibiotic USE and antibiotic resistance (PAUSE): a qualitative interview study Oliver van Hecke 1 April 2017 31 December 2017
380. The feasibility of examining cardiovascular event rates with different add-on therapies to metformin for type 2 diabetes mellitus using primary care data through benchmarking results against randomised controlled trials. Manuj Sharma 1 February 2018 30 September 2018
339. The effectiveness of CVD preventative treatment in a multi-morbid population Rachel Denholm 1 July 2017 31 July 2018
357. Acceptability and feasibility of a new weight specific quality of life measure as a screening tool in primary care Yemi Oluboyede 1 April 2017 31 March 2018
343. ‘I’m fine’: exploring patient and carer assertions of status in advanced COPD and clinical implications for primary care Robbie Duschinsky 1 April 2017 31 March 2018
344. Identifying effective ways to increase the uptake of cessation support among smokers: systematic review and meta-analysis Joanne Emery 1 July 2017 31 December 2018
345. The association between continuity of primary care and mortality and emergency hospitalisation for older patients with complex multimorbidity Simon Griffin 1 April 2017 31 October 2017
350. Gout and Neurodegenerative Disorders: A retrospective cohort study in the Clinical Practice Research Datalink. Lorna Clarson 1 April 2017 30 September 2017
353. Quantifying severity of chronic conditions in English Primary Care using the Clinical Practice Research Datalink Evan Kontopantelis 1 April 2017 31 March 2018
361. External Validation of the Familial Hypercholesterolaemia Case Ascertainment Tool (FAMCAT) Stephen Weng 1 April 2017 31 March 2018
351. Subgrouping and TargetEd Exercise pRogrammes for OsteoArthritis: the role of comorbidity Melanie Holden 1 April 2017 31 May 2018
354. An investigation of factors which are associated with successful transitions from GP Specialty Training Programmes to long-term careers in NHS general practice Sharon Spooner 1 April 2017 30 June 2018
340. Association of blood cholesterol and lipid-lowering treatments with post-stroke dementia: cohort studies using Clinical Practice Research Datalink and Cognitive Function and Ageing Studies Zhirong Yang 1 April 2017 30 September 2018
341. What are the barriers and facilitators when conducting CTIMPs in a primary care setting: experiences and lessons from the PROPS trial. Ricky Mullis 1 April 2017 31 December 2017
372. Epidemiology of Sepsis in adults in Primary Care: an exploratory study using the Hampshire Health Record Michael Moore 1 April 2017 31 March 2018
376. Antibiotic Negotiations Conversation Analytic Project Geraldine Leydon 1 April 2017 28 February 2018
377. Managing malnutrition in later life: exploring the views and dietary practices of older people at risk of malnutrition and their carers Kalpa Kharicha 1 June 2017 28 February 2019
363. Non-pharmacological approaches to optimising vaccine effectiveness: the development of an effective and acceptable intervention for primary care Kieran Ayling 1 April 2017 31 March 2018
365. Statin use in COPD patients and risk of exacerbations: a cohort study using data from English primary care Margaret Smith 1 August 2017 31 March 2018
379. Population-calibrated inference for incomplete continuous variables via weighted multiple imputation Tra My Pham 1 October 2017 30 September 2018
359. Is prevention better than cure: assessing dementia risk in primary care Louise Robinson 1 October 2017 30 September 2018
364. Body composition measurement and its prognostic value in aging and disease Carmen Piernas-Sanchez 1 September 2017 31 August 2018
369. Patient reported outcome measures for acne: mixed methods validation study. Beth Stuart 1 April 2017 31 March 2018
375. Standardised Chinese herbal medicine for oligomenorrhoea and amenorrhoea in polycystic ovary syndrome: Nominal group technique and observational non-randomised study Merlin Willcox 1 April 2017 31 March 2018

FR 12

Title Principal Investigator Start date End date
332. Improving identification of familial hypercholesterolaemia in primary care using a new case ascertainment tool (FAMCAT) Nadeem Qureshi 1 July 2016 30 December 2018
330. Developing and evaluating a measure of inappropriate polypharmacy in primary care Rupert Payne 1 July 2016 30 June 2018
331. Quantifying severity of chronic conditions in English Primary Care using the Clinical Practice Research Datalink Evan Kontopantelis 4 July 2016 5 July 2019
333. A randomised controlled trial on the effectiveness of GP promotion of e-cigarettes in supporting reduced smoking and abstinence in hardcore smokers with smoking-related chronic disease 1 October 2016 30 September 2018
334. Developing clinically useful subgroups from urine samples reported as ‘mixed growth’ to guide primary care clinicians Gail Hayward 1 January 2017 1 January 2018
335. OPtimising Treatment for MIld Systolic hypertension in the Elderly (OPTiMISE) James Sheppard 1 October 2016 31 May 2019
336. Feasibility study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for lower respiratory tract infection in adults Michael Moore 1 January 2017 31 December 2018

FR 11

Title Principal Investigator Start date End date
327. Open prescribing Ben Goldacre 1 October 2015 30 September 2017
329. Weight management intervention for postnatal women embedded within the national child immunisation programme in primary care Susan Jebb 1 June 2016 31 August 2017
297. Patient-led non-pharmacological management of ACuTe FLAREs of knee osteoarthritis in primary care settings: a feasibility and pilot study Martin Thomas 1 April 2016 31 March 2017
300. IMprovIng access to DemeNtiA caRE for BriTish ethnic minorities Waquas Waheed 1 April 2016 30 September 2016
306. Exploring the views of key stakeholders on an intervention aimed at improving the safety of prescribing of GP Associates in training Richard Knox 1 April 2016 31 March 2017
312. DiSCeRN - eviDence Synthesis of Clinical Study reports for NOACs (DiSCeRN - phase 1) Kamal Mahtani 1 April 2016 30 September 2016
314. The Evidence of Effects Page: Refinement of a tool for optimising evidence-based informed treatment decisions In Clinical practice (The EEPIC-1 study) David Nunan 1 April 2016 31 March 2017
323. An examination of STI testing influences for young people in primary care Lorraine McDonagh 1 April 2016 31 January 2017
325. A risk prediction tool to identify pregnant women at high risk of postnatal depression Sarah Hardoon 1 February 2016 31 January 2017
326. A systematic review of the measurement of implementation fidelity in primary care trials Rebecca Barnes 1 July 2016 1 April 2017
286. Systematic review of community detoxification for alcohol dependency David Kessler 1 April 2016 31 December 2016
287. Impact of hospital admission upon patterns of primary care prescribing Rupert Payne 1 April 2016 31 March 2017
288. Identifying the most appropriate treatment for IAPT attendees with depression and co-morbid personality difficulties Katrina Turner 1 April 2016 31 March 2017
289. The Tip of the Iceberg: Identifying Patients with Heart Failure and Preserved Ejection Fraction (HFpEF) in Primary Care Christi Deaton 2 March 2016 1 September 2016
290. Identifying patients at raised risk of stroke due to paroxysmal or persistent atrial fibrillation in primary care populations Duncan Edwards 1 April 2016 31 March 2018
291. Towards person-centred care: development of a patient support needs tool for patients with advanced Chronic Obstructive Pulmonary Disease (COPD) in primary care Morag Farquhar 1 February 2016 31 August 2016
292. Validation of existing risk prediction models for prostate cancer using data from UK BioBank and EPIC-Norfolk Greg Irving 1 March 2016 28 February 2017
293. Developing and pre-testing a tailored interactive voice response (IVR) intervention to support adherence to anti-hypertensive medications Katerina Kassavou 1 September 2016 31 March 2017
294. Exploring patient barriers to the diagnosis of Giant Cell Artheritis in primary care James Prior 1 April 2016 31 March 2017
296. Illness perceptions and explanatory models in patients with type 2 diabetes and co-morbid depression. Athula Sumathipala 1 April 2016 31 March 2017
298. Burnout in general practitioners: a systematic review of relationships with patient safety and a feasibility study of the measurement of burnout Maria Panagioti 1 April 2016 31 October 2016
299. Characterising the primary care population with frailty to better stratify and target healthcare interventions David Reeves 1 April 2016 30 September 2017
301. Determinants and burden of differing health trajectories in the very old Rachel Duncan 1 September 2016 31 August 2017
302. Collaborating with patients to improve patient safety in primary care Susan Hrisos 1 January 2016 30 October 2016
303. Exploring the relationship between frailty, multi-morbidity and the use of healthcare resource by the very old. Louise Robinson 1 April 2016 30 June 2017
304. Unintended effects of novel oral anticoagulants (NOAC) vs warfarin in real world settings Julia Hippisley-Cox 1 April 2016 31 March 2017
305. Is systematic identification of Familial Breast Cancer risk more cost-effective than the currently recommended opportunistic approach in primary care? Matthew Jones 1 April 2016 31 December 2016
307. Trends in NHS prescribing of dual NRT (DNRT) and varenicline in pregnancy and effects on infants Lisa Szatkowski 1 April 2016 31 December 2016
308. Developing CONSORT guidelines for lay summaries on clinical trials, and evaluating their impact. Ben Goldacre 1 April 2016 31 July 2016
309. Systematic review to assess the impact of point-of-care tests on patients and healthcare processes Clare Goyder 1 April 2016 31 July 2016
310. Blood pressure in pregnancy: a discourse analysis of official, informal and online information for pregnant women. Lisa Hinton 1 September 2016 30 November 2016
313. Availability of withdrawn anorexigenics for sale in search engines Tim Muntinga 1 April 2016 30 March 2017
315. Development of Primary Care Trial Management System Ly-Mee Yu 1 April 2016 31 March 2017
316. Exploring primary care patients’ experience of an internet intervention ‘Healthy Paths’ for emotional distress Adam Geraghty 1 May 2016 30 April 2017
317. Rosehip for osteoarthritis of hip, hand and knee: A Cochrane review Christian Mallen 1 April 2016 31 March 2017
318. Screening for Atrial Fibrillation using Economical and Accurate TechnologY (SAFETY) – a pilot study Mark Lown 1 April 2016 31 March 2017
319. Experiences of lower limb cellulitis and cellulitis prevention: qualitative interview study Miriam Santer 1 March 2016 30 November 2016
320. Clustering at the GP and practice level in individually randomised studies – a review of 10 years of primary care trials Beth Stuart 1 April 2016 30 November 2016
321. MOVA: Mindfulness in Recurrent Ovarian Cancer – a feasibility study Sam Watts 1 May 2016 30 April 2017
322. Exploring the use of the Internet as a support tool for older family carers of people with dementia Nathan Davies 1 April 2016 31 March 2017
324. Patients’ and primary care professionals’ views on, and preferences for, a digital diabetes prevention programme (DDPP) among individuals at high risk of developing diabetes Elizabeth Murray 1 January 2016 31 December 2016
311. Cochrane Tobacco Addiction Group twentieth anniversary priority setting (CTAG taps) Nicola Lindson-Hawley 1 April 2016 31 December 2017
328. GP workloads Richard Hobbs 1 October 2015 30 September 2016

FR 10

Title Principal Investigator Start date End date
243. Understanding the volume and content of general practice consultations: the 5th National Morbidity Study Chris Salisbury 1 January 2016 31 August 2017
121. CANDID Paul Little 1 October 2015 30 September 2016
170. ATAFUTI Michael Moore 1 October 2015 28 February 2016
Deaths and hospital admissions during cold weather: derivation and validation of a tool to help primary care identify vulnerable people Richard Morris 1 March 2016 31 August 2017
282. Doctors as patients - a qualitative study to explore the barries and facilitators to help - seeking by General Practitioners with mental health problems: improving access to care Ruth Riley 1 January 2016 28 February 2017
283. Administrative data to evaluate new models of primary care Martin Roland 1 January 2016 31 December 2017
284. Harnessing resources from the internet to maximise outcomes from GP consultations (HaRI): a qualitative study Fiona Stevenson 1 January 2016 31 December 2017

FR 9

Title Principal Investigator Start date End date
254. Can metaphors usefully represent underlying CBT principles for Medically Unexplained Symptoms (MUS), and how acceptable are such generic and MUS specific metaphors to patients and practitioners? Athula Sumathipala 1 October 2015 30 June 2016
255. The role of systemic inflammatory diseases in long-term morbidity and mortality: a retrospective, matched-cohort study in the Clinical Research Practice Datalink Lorna Clarson 1 October 2015 30 September 2016
257. The diagnostic and prognostic value of the symptom of shortness of breath in primary care: a cohort study Ying Chen 1 October 2015 30 September 2016
258. Predicting individual risk of future hip and knee replacement for osteoarthritis Dahi Yu 1 October 2015 30 September 2016
259. Empowering People to Help Speak Up about Safety (EPHESUS) in Primary Care Sarah Knowles 1 January 2016 30 July 2016
261. Assessing dementia risk in general practice: a qualitative study of the attitudes and views of patients and the public. Louise Robinson 1 October 2015 30 September 2016
263. Can a frailty index be used in primary care practice to improve prognostication at the end of life? A multi-method study Barbara Hanratty 1 October 2015 30 September 2016
264. Keeping active: maintenance of physical activity in older people after an exercise intervention Denise Kendrick 1 October 2015 30 September 2016
265. Anticholinergic drugs and the risk of dementia: a nested case control study Carol Coupland 1 October 2015 30 September 2016
266. Implementing diagnostic genetic testing for familial hypercholesterolaemia in primary care: qualitative study Nadeem Qureshi 1 October 2015 30 September 2016
267. Blood pressure self-monitoring individual patient meta-analysis of registered trials; sub group analyses in a multi-morbid population Katherine Tucker 1 October 2015 30 September 2016
268. Risk factors for influenza-related complications in children: a retrospective cohort study using linked routinely collected data from the Clinical Practice Research Datalink and National Pandemic Flu Service Kay Wang 1 October 2015 30 September 2016
269. Evidence synthesis for economic decision models of primary care diagnostics Tom Fanshawe 1 October 2015 31 December 2015
270. Getting it right for autistic patients: a qualitative study Sara Ryan 1 October 2015 30 June 2016
271. The Association Between Evidence-Based Medication Use And Unplanned Hospital Admissions: A National Observational Study in Primary Care Niklas Bobrovitz 1 October 2015 30 September 2016
272. The development of a digital GP behaviour change intervention to support GPs in the delivery of evidence based practice around the management of PSA screening and active surveillance in primary care Sam Watts 1 April 2016 31 March 2017
273. Investigating the impact of a short-course MBSR-based mindfulness intervention on patients with difficult-to-manage asthma 1 October 2015 31 March 2016
274. Southampton communication study (SoCS): managing multiple health concerns Geraldine Leydon 16 November 2015 14 November 2016
275. UNderstanding medIcal and non-medical anTibiotic prescribing for rEspiratory tract infections in primary care out of hours services: a qualitative analysis Geraldine Leydon 1 October 2015 29 September 2016
276. Andrographis paniculata for symptomatic relief of lower respiratory tract infection: A Cochrane review Beth Stuart 1 October 2015 30 September 2016
277. Assessing dementia risk in general practice: a qualitative study of the attitudes and views of primary care health professionals Greta Rait 1 October 2015 30 June 2016
278. Assessment of sarcopenia in primary care:identifying potential practical tools for assessment and scope for intervention Goya Wannamethee 1 October 2015 30 April 2016
279. Process evaluation of the Digital Alcohol Management on Demand (DIAMOND) feasibility randomised controlled trial Fiona Hamilton 1 October 2015 30 September 2016
280. Online structured education with email facilitation for people with type 2 diabetes: feasibility trial Elizabeth Murray 1 October 2015 30 September 2016
250. Literature review of exercise interventions for peripheral arterial disease. Ricky Mullis 1 October 2015 30 September 2016
389. Antidepressants for Insomnia - Cochrane Review Hazel Everitt 1 February 2014 30 October 2014
252. Children and Adolescents with Musculoskeletal Pain in primary care: CAM-Pain Feasibility Study Kate Dunn 1 October 2015 30 September 2016
260. Investigation of the factors behind the training choices of junior doctors which result in inadequate recruitment to general practice careers. Sharon Spooner 1 October 2015 31 December 2016
262. The role of primary care in liver disease: early detection and end of life care? A qualitative study of the perceptions of primary health care professionals Barbara Hanratty 1 October 2015 30 September 2016
251. Patterns of medication use and polypharmacy at the end of life Rupert Payne 1 October 2015 30 September 2017

Evidence synthesis working group

The collaboration will be conducting 18 high impact systematic reviews, under four workstreams.

Find out more