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Benefits of Aldosterone Receptor Antagonism in Chronic Kidney Disease (BARACK D) Trial
About 1 in 10 people are living with reduced kidney function because mild chronic kidney disease (CKD) is common and kidney function declines with age. Around 1.3% of those affected progress to severe kidney disease requiring dialysis or transplantation, but CKD also puts people at high risk of cardiovascular disease, in particular stroke, heart failure and sudden death due to abnormal heart rhythms. There has been little research done in this area but we know that even people with very mild CKD have premature stiffening and reduced function of their heart and major arteries. We have recently shown that in 112 people with mild CKD from a specialist hospital kidney clinic, a tablet commonly used to treat raised blood pressure or as a water tablet improves their heart function and decreases stiffness in the blood vessels. There is evidence that this type of drug can also delay the worsening of kidney function in CKD.