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Three SPCR case studies have provided evidence in the latest of the NIHR Dissemination Centre's themed reviews which discusses physiotherapy for musculoskeletal heath and wellbeing.

Subgrouping and TargetEd Exercise pRogrammes for OsteoArthritis: the role of comorbidity

Due to publish 2018
Melanie Holden, Keele University

This study is investigating whether individuals with knee osteoarthritis (OA) who also have other health conditions such as asthma, diabetes and heart disease, would benefit from an exercise programme. The researchers will complete a systematic review of the literature to look at the benefits of exercise for knee OA and whether information on the influence of other health conditions has also been collected. They will also re-analyse three clinical trials to investigate whether individuals with knee OA who have other health conditions benefit from exercise. The results will provide a better understanding as to whether a targeted treatment approach may be beneficial for those with knee OA and other health conditions.

Comparative Effectiveness of Treatment Options for Subacromial Shoulder Conditions: A Network Meta-Analysis (CETOSS)

Due to publish 2018
Danielle van der Windt, Keele University

This network meta-analysis aimed to combine direct and indirect evidence about treatment for adults with subacromial shoulder conditions (SSC) to determine the most effective treatment strategy. The researchers identified 142 trials of 21 different treatments for SSCs. Effectiveness of treatment options for relieving pain and improving function were summarised in comparison to each other, and treatment options were ranked based on their effectiveness at short (<6 weeks), medium (up to three months) and long (>6 months) follow up times. There was large variation between trials and trials often had small sample sizes. Full results will be submitted for publication in Summer 2018. van der Windt, Babatunde O, Ensor J, Littlewood C, Jordan J, Roddy E, et al. Comparative Effectiveness of Treatment Options for Subacromial Shoulder Conditions: A Network Meta-Analysis (CETOSS).

Individual patient data meta-analysis of trials investigating the effectiveness of exercise in patients with knee and hip osteoarthritis. (STEER OA) (active 2017-2019)

Nadine Foster / Melanie Holden - Keele University

Exercise is a recommended core treatment for people with knee and hip osteoarthritis (OA), however, the effects on pain and function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify subgroups of people with knee and hip OA that do/donot respond to exercise and to different types of exercise and identify mediators of the effect of therapeutic exercise for reducing pain and improving physical function. STEER OA is a systematic review and individual data meta-analysis of existing randomised trials and the results will facilitate better targeting of future exercise interventions. Protocol: Holden MA, Burke DL, Runhaar J, et al and the OA Trial Bank. Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): A systematic review update and individual participant data meta-analysis protocol. BMJ Open 2017 Dec 22;7(12):e018971. doi: 10.1136/bmjopen-2017-018971


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