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  1. What are the benefits and harms of cholesterol lowering drugs to prevent CVD based on clinical study reports and summary of regulatory comments? (Stage 1 review)
  2. Do new oral anticoagulation drugs in patients with Atrial Fibrillation improve outcomes? (Systematic review of clinical study reports and summary of regulatory comments)
  3. What are the benefits and harms of Glucagon-like peptide-1 (GLP-1) [1] analogues in the summary of regulatory comments)
  4. What are the benefits and harms of Mysimba in the treatment of obesity? (Systematic review of clinical study reports and summary of regulatory comments)
  5. What is the role of genetics in primary care? A critical interpretive synthesis of current attitudes towards genetics in primary care, and a review of therapeutic areas with potential to benefit from genetic profiling.
  6. Using Pedometers to Increase Physical Activity and Improve Health

 Workstream leads

Igho Onakpoya (Oxford); Carl Heneghan (Oxford), Ben Goldacre (Oxford)