Discontinuation of menopausal hormone therapy and risk of fracture: nested case–control studies using routinely collected primary care data
Yana Vinogradova, Barbara Iyen, Prof Tahir Masud, Lauren Taylor, Prof Joe Kai, MDa
Background Women benefit from reduced fracture risk while using menopausal hormone therapy. However, information on risks after stopping menopausal hormone therapy is scarce and inconsistent, with no information on longer-term fracture risk as women age. We aimed to produce robust estimates of fracture risk among past users for the longest possible period after discontinuing therapy.