Identifying novel biomarkers suitable for early detection of Intrathoracic cancers in primary care: a systematic review.
Wasim Hamad, Natalia Calanzani, Dawnya Behiyat, Rachel Boscott, Jaime Peters, Georgia Jenkins, Bogdan Grigore, Richard Neal, Fiona Walter
Review objectives Are there any novel biomarkers for detection and diagnosis of intrathoracic cancers that are suitable for use in primary care? To address this review question, we will identify and describe existing validated biomarkers for the detection/diagnosis of intrathoracic (primary lung/bronchus/trachea, mesothelioma, and thymoma) cancers, focusing on their: • Diagnostic performance across different population groups (such as setting, symptomatology, health behaviors, or other patient characteristics) • Classification based on sample source (such as blood, saliva, breath, or sputum) and molecular function (such as proteins, volatile organic compounds, microRNAs, and others) • Potential relevance to populations such as primary care where cancer prevalence is low compared to specialist settings.