Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

  • 1 April 2020 to 31 March 2021
  • Project No: 486
  • Funding round: FR19

Non-steroidal anti-inflammatory (NSAID) medications, such as ibuprofen, are often recommended or prescribed when patients present with what doctors believe is an infection that can be safely managed at home, without the need for antibiotics. 

However, some trials in patients with respiratory tract infections, like coughs and colds, and urinary tract infections (UTI) have indicated more complications and longer illness in those patients who have used NSAIDs.  These studies were relatively small and therefore we can’t rule out these being chance findings.  However, if these medications are associated with an increased risk of complications, it is important that we reconsider our current guidance on the management of illnesses at home.

This study aims to use a large, representative primary care database to explore the extent to which NSAID prescriptions are associated with high rates of complications.  We will explore individuals with respiratory tract and urinary tract infections who are prescribed NSAIDs have a higher risk of going on to develop a complication, after controlling for other factors, including their age and any other health conditions. 


Paul Little, Michael Moore, Samantha Richards-Hall (Southampton)


Amount awarded: £11 222.00

Projects by themes

We have grouped projects under the five SPCR themes in this document

Evidence synthesis working group

The collaboration will be conducting 18 high impact systematic reviews, under four workstreams.